Development of immunoradiometric assay for quantitative determination of free prostate-specific antigen
نویسندگان
چکیده
منابع مشابه
Preparation of prostate specific antigen standards for immunoradiometric assay
Background: Immunoradiometric assay is one of the most common and precise methods for determination of prostate specific antigen (PSA) in clinical laboratories. Usual use of human serum in routine assays has many disadvantages such as easy contamination and precipitation, instability and unavailability. Thus in order to avoid these problems the artificial matrix was used which acts sim...
متن کاملpreparation of prostate specific antigen standards for immunoradiometric assay
background: immunoradiometric assay is one of the most common and precise methods for determination of prostate specific antigen (psa) in clinical laboratories. usual use of human serum in routine assays has many disadvantages such as easy contamination and precipitation, instability and unavailability. thus in order to avoid these problems the artificial matrix was used which acts similar to h...
متن کاملDetermination of prostate-specific antigen in serum by immunoradiometric assay.
A better understanding is needed of the role of pre-analytical factors if prostate-specific antigen (PSA) is to be reliably used as a tumor marker. Reports on the analytical performance of TANDEM-R PSA (Hybritech, Inc., San Diego, CA) differ considerably with respect to detection limit and imprecision, differences that might be due (e.g.) to the use of different control matrices, to between-bat...
متن کاملPreparation of prostate specific antigen standards for immunoradiometric assay
Prostate cancer is the sixth most common cancer in the world, the third most common cancer in men. In 2000, the number of new cases of prostate cancer was estimated at 513000 worldwide and this disease accounts for 9.7% of all cancers in men (1, 2). Thus early detection and local treatment have been advocated in an effort to influence the significant morbidity and mortality associated with the ...
متن کاملEvaluation of a two-site immunoradiometric assay for measuring noncomplexed (free) prostate-specific antigen.
Serum prostate-specific antigen (PSA) in men is present as two different molecular forms separable by gel-filtration chromatography (GFC). We have evaluated a two-site IRMA that measures only the noncomplexed (free) form of PSA (F-PSA). Verification that the F-PSA assay measures solely F-PSA was obtained by assaying GFC-fractionated serum samples with both the F-PSA IRMA and a commercial PSA as...
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ژورنال
عنوان ژورنال: Yugoslav Medical Biochemistry
سال: 2005
ISSN: 0354-3447,1452-8193
DOI: 10.2298/jmh0502129j